What is Xeomin?

Xeomin is a neuromodulator that is in the same class as Botox®. Xeomin  is FDA approved for aesthetic use in the human face including the treatment of moderate to severe wrinkles in the glabella. It is also has therapeutic indications and is the first-line therapy for blepharospasm. Both Botox and Xeomin can be used throughout the face in a safe fashion. Most commonly, both are utilized in the forehead, around the eyes (crows feet), around the lip lines, and along the neck. Bruising is uncommon, and swelling resolves within an hour. Each of these treatments are common “lunchtime” interventions.

There is no mistaking the brand presence of Botox®, but also consider that Botox® was introduced back in the 1980’s. There have been a number of innovations in neuromodulation since the landmark discovery of Botox. Xeomin is the next step in the neuromodulator market. It provides the purest form of neuromodulation on the market, spares the possibility of preservative allergy/rejection, and acts faster while lasting just as long as Botox®. Welcome to the next level of neuromodulators.

Xeomin is Uniquely Purified

Xeomin is the only highly purified neurotoxin on the market that uses a patented process called, Xtract Technology. Xeomin was created and is produced by Merz Aesthetics, a 112 year pharmaceutical company that focuses on nothing but aesthetic products. Their scientists developed the Xtract Technology to remove all of the unnecessary proteins away from the active toxin molecule. Their goal was to achieve an end-product that was as pure as possible. That makes sese, right? Why would anyone want impurities in a product that they would inject into their face? If they could minimize those impurities, wouldn’t they achieve a better purifies toxin than other available products on the market? So, using their special Xtract Technology, Merz is able to eliminate all the unecessary proteins that can result in immunogenicity and dose creep. And, in a double-blind patient satisfaction study, Xeomin had a 93% satisfaction rate at month four and that’s 3% higher than Botox. In a world where some of our patients are more conscious than ever about what they put in their body’s, Xeomin is a great option.

Xeomin.com homepage
Before and after Xeomin frown lines.

Xeomin® vs Botox®

Xeomin has the same parent molecule as Botox, but unlike Botox, it begins working within 1-2 days rather than over 10-14 days. This is one of the main innovations that Xeomin brings to the table. The reason why it acts faster is because unlike Botox, Xeomin does not have a preservative protein. When Botox is injected, the botulinum molecule must free itself from its preservative protein, and then it is free to bond with the facial muscles. It bonds to the muscle, and the muscle relaxes. Once the muscle relaxes, the wrinkles fade away. Again, with Xeomin, there is no preservative protein. Xeomin is immediately available to the muscle receptors. It starts to bind immediately, and reduce wrinkling at a markedly faster rate, and at a steadier pace. No preservatives in the mixture allows for a higher activity of the active molecule following injection.

There are also significant differences in how Botox® and Xeomin® feel to the patient. As a patient myself, I have received both Botox® and Xeomin®. Xeomin feels much lighter and more natural than Botox, in my opinion. With Xeomin, the wrinkles disappear, but I still maintain normal motion. Botox tends to be a bit stronger, in my opinion. It has a heavier feeling on the brow, and it tends to limit muscle movement to a greater degree.

As we always preach at Ocean Drive Plastic Surgery, one solution does not fit everyone. We use Botox in patients who want a more dramatic result from their neuromodulator. We use Botox in patients who do not mind that heavy sensation, and in patients that want to curtail muscle movement. For patients that want less muscle movement, and more natural facial function, we have found that Xeomin offers a superior result to those clients that want to maintain muscle function but limit the amount of facial lines they see in the mirror.


Xeomin Before
Xeomin Before


Xeomin After
Xeomin After
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